Fundamental understanding of a molecule‘s normal function could inform treatments for a variety of brain disorders
Category: research Video duration: Fundamental understanding of a molecule‘s normal function could inform treatments for a variety of brain disorders
A team of investigators in John Chappell’s lab at the Fralin Biomedical Research Institute at VTC made a discovery that could inform new therapies.
The micro vasculature is critical to the health and maintenance of all the tissues of our body. What we discovered in this paper is a new protein isoform that has not previously been reported. We're really excited about this. How is this protein regulating the function of the micro vasculature? In what scenarios, in certain pathologies is the level of that protein changing? This was a bit of a surprise because the literature up to this point has said it's a biomarker of disease in Alzheimer's in particular. But we're finding actually a molecule that exists naturally. If this molecule changes its levels or its levels change due to aging or due to some other input, changes in diet, it could then have an impact on the stability of the blood vessel wall. If that happens, then the blood vessels aren't doing their job in supplying enough oxygen and nutrients to the neurons that continuously fire. That help us think and learn. Dysfunctional vasculature is associated with numerous pathologies. Heart disease, cancer in the brain, particularly stroke, Alzheimer's, these things all involve dysfunctional vasculature. If we could figure out the functionality of this new isoform, figure out if it could be a target to use, if this kind can improve the recovery and the integrity of the blood visas. Which will in turn improve the general outcome and the recovery of the patients from different diseases including to. And now the excitement continues, right? Because you get to kind of follow that and hopefully be able to apply it to real world scenarios and pathologies to improve lives, which is why we're here doing this.